English
norskBlar i forfatter "Okoli, Arinze Stanley"
Viser treff 1-9 av 9
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Antimicrobial resistance due to the use of biocides and heavy metals: a literature review
(Research report; Forskningsrapport, 2016-12-09)In June 2016,the Norwegian EnvironmentAgencyrequestedthe Norwegian Scientific Committee for Food Safety (VKM) to conducta literature reviewregardingdevelopment of bacterial resistance to biocides and heavy metals and cross-resistance to antimicrobial agents(e.g.,antibiotics)in bacteria, with the following mandate: <br><br>1.List chemical substancesthat may contribute to increased antimicrobial ... -
Antimicrobial resistance in wildlife – potential for dissemination: Opinion of the Panel on Microbial Ecology of the Norwegian Scientific Committee for Food and Environment
(Research report; Forskningsrapport, 2018-03-16)<p>Antimicrobial resistance (AMR) is recognised as one of the greatest public health concerns of our time. The development of AMR occurs in nature as a defence by microbes against naturally occurring antimicrobials. However, the selective pressure, generated by the use of antimicrobial agents in human and veterinary medicine, livestock and plant production as well as aquaculture practices, is the ... -
CRISPR/Cas9-Mediated Gene Editing in Salmonids Cells and Efficient Establishment of Edited Clonal Cell Lines
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-19)Finfish production has seen over three-fold increase in the past 30 years (1990–2020), and Atlantic salmon (A. salmon; salmo salar) accounted for approximately 32.6% of the total marine and coastal aquaculture of all finfish species in the year 2020, making it one of the most profitable farmed fish species globally. This growth in production is, however, threatened by a number of problems which can ... -
CRISPR/Cas9—Advancing Orthopoxvirus Genome Editing for Vaccine and Vector Development
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-22): The clustered regularly interspaced short palindromic repeat (CRISPR)/associated protein 9 (Cas9) technology is revolutionizing genome editing approaches. Its high efficiency, specificity, versatility, flexibility, simplicity and low cost have made the CRISPR/Cas9 system preferable to other guided site-specific nuclease-based systems such as TALENs (Transcription Activator-like Effector ... -
Hazard Characterization of Modified Vaccinia Virus Ankara Vector: What Are the Knowledge Gaps?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-29)Modified vaccinia virus Ankara (MVA) is the vector of choice for human and veterinary applications due to its strong safety profile and immunogenicity in vivo. The use of MVA and MVA-vectored vaccines against human and animal diseases must comply with regulatory requirements as they pertain to environmental risk assessment, particularly the characterization of potential adverse effects to humans, ... -
Health and environmental risk evaluation of microorganisms used in bioremediation. Scientific Opinion of the Panel on Microbial Ecology of the Norwegian Scientific Committee for Food Safety
(Research report; Forskningsrapport, 2016)In 2015, The Norwegian Environment Agency requested the Norwegian Scientific Committee for Food Safety (VKM) to collate an overview of bioremediation of polluted ground based on bioaugmentation described in literature for the degradation of various types of pollutants, (including hydrocarbons, heavy metals, chlorinated compounds, explosives etc.).The assessment of genetically modified microorganisms ... -
Knowledge base for the assessment of environmental risks by the use of genetically modified virus-vectored vaccines for domesticated animals. Scientific Opinion of the Panel on Microbial Ecology of the Norwegian Scientific Committee for Food Safety
(Research report; Forskningsrapport, 2016)The Norwegian Scientific Committee for Food Safety (VKM) was requested by the Norwegian Environment Agency in November 2015 to develop a knowledge base for assessment of the environmental risks related to the use of genetically modified (GM) virus vaccine vectors for vaccination of domesticated animals. The Agency requested that the task be conducted in the form of a desk study with the following ... -
Molecular characterization and phylogenetics of Fennoscandian cowpox virus isolates based on the p4c and atip genes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)Background: Cowpox virus (CPXV), a rodent-borne Orthopoxvirus (OPV) that is indigenous to Eurasia can infect humans, cattle, felidae and other animals. Molecular characterization of CPXVs isolated from different geographic locations is important for the understanding of their biology, geographic distribution, classification and evolution. Our aim was to characterize CPXVs isolated from Fennoscandia ... -
Sustainable use of CRISPR/Cas in fish aquaculture: the biosafety perspective
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-25)Aquaculture is becoming the primary source of seafood for human diets, and farmed fish aquaculture is one of its fastest growing sectors. The industry currently faces several challenges including infectious and parasitic diseases, reduced viability, fertility reduction, slow growth, escapee fish and environmental pollution. The commercialization of the growth-enhanced AquAdvantage salmon and the ...
